Friday 140530

1100 after Murph
1100 after Murph

Workout

5k Row or 3 mile Run

Light bedrooms ‘link to obesity’

Woman asleep

Sleeping in a room with too much light has been linked to an increased risk of piling on the pounds, a study shows.

A team at the Institute of Cancer Research in London found women had larger waistlines if their bedroom was “light enough to see across” at night.

However, they caution there is not enough evidence to advise people to buy thicker curtains or turn off lights.

The study of 113,000 women was published in the American Journal of Epidemiology.

The women were asked to rate the amount of light in their bedrooms at night as:

  • Light enough to read
  • Light enough to see across the room, but not read
  • Light enough to see your hand in front of you, but not across the room
  • Too dark to see your hand or you wear a mask

Their answers were compared to several measures of obesity. Body Mass Index, waist-to-hip ratio and waist circumference were all higher in women with lighter rooms.

Prof Anthony Swerdlow, from the Institute of Cancer Research, told the BBC: “In this very large group of people there is an association between reported light exposure at night and overweight and obesity.

“But there is not sufficient evidence to know if making your room darker would make any difference to your weight.

“There might be other explanations for the association, but the findings are intriguing enough to warrant further scientific investigation.”

Body Clock

One possible explanation is that the light is disrupting the body clock, which stems from our evolutionary past when we were active when it was light in the day and resting when it was dark at night.

Light alters mood, physical strength and even the way we process food in a 24-hour cycle.

Artificial light is known to disrupt the body clock by delaying the production of the sleep hormone melatonin.

Body Clock

Prof Derk-Jan Dijk, from the Surrey Sleep Centre, said there would be no harm in trying to make bedrooms darker.

He told the BBC: “People in general are not aware of the light present in their bedroom, I think people should assess their bedroom and see how easy it would be to make it darker.”

Street lights, some alarm clocks and standby lights on electrical equipment such as televisions could light a room, he said.

“Overall this study points to the importance of darkness,” he concluded.

Cancer

The study Read more Friday 140530

Sunday 130526

Workout

5k Run or Row

From CNN

A workout a day may keep cancer away

By Matt Sloane, CNN updated 10:58 AM EDT, Thu May 16, 2013
Exercise may be an important tool in preventing cancer, or in improving survival after diagnosis, new research shows.
Exercise may be an important tool in preventing cancer, or in improving survival after diagnosis, new research shows.

Less cancer treatment may be better, researchers say

(CNN) — Less cancer treatment may be better, and being in good physical shape may help keep cancer away, according to the latest research being presented at the largest convergence of cancer experts worldwide.

The American Society of Clinical Oncology meets at the end of the month in Chicago. A briefing was held Wednesday for journalists covering the meeting. Here are some highlights from studies being presented:

Exercise may keep cancer away

Getting into shape may help you ward off cancer — or boost your survival chances if you are diagnosed, according to a new study.

Researchers from the University of Vermont studied more than 17,000 men for close to 20 years. They found those who exercised the most were 68% less likely to develop lung cancer and 38% less likely to develop colorectal cancers than the least active men

Among those men who did develop either of those two cancers or prostate cancer, exercise helped reduce the risk of death by 14% for each incremental increase in fitness level.

Boosting your immune system to fight cancer

Among the other six studies highlighted, two looked at new approaches in immunotherapy treatments — drugs that train the immune system to recognize and kill cancer cells.

One study found that a new antibody, known only as MPDL3280A, shrank tumors in 21% of the patients studied, all of whom were suffering from melanoma, lung or kidney cancers.

The drug was well-tolerated at all dose levels by the majority of patients, and reports of serious adverse reactions were infrequent, officials said.

Researchers presented results from the first phase of a clinical trial of MPDL3280A. The purpose of these initial trials is to establish the safety and dosage guidelines for an investigational drug. If it’s found to be safe, as in this case, it must be tested in much bigger trials with many more people. So far, the early results are promising, according to researchers.

The second study found that the combination of two immunotherapy drugs — Yervoy and Nivolumab — can help shrink melanoma tumors.

More than half of study participants saw their tumors shrink by more than half, and nearly a third saw their tumors shrink by 80%, just in the first 12 weeks of treatment, according to the study author.

Before Yervoy received Food and Drug Administration approval two years ago, patients with melanoma — the deadliest form of skin cancer — had no real treatment options. Nivolumab still needs FDA approval.

Researchers have known that at some point, cancer cells figure out how to circumvent Yervoy and tumors start to grow again, but this study suggests that a combination of these drugs can lengthen the benefit of Yervoy.

“After years of not having success in immunotherapy, we now have two (different studies) showing significant progress,” said Dr. Sandra Swain, president of the American Society of Clinical Oncology. “With these two therapies, we’re seeing very rapid, profound and long-lasting tumor shrinkage, which is something that hasn’t been seen before with immunotherapies.”

Less is more

Three additional studies presented in the Wednesday briefing examined existing therapies for various cancers and which ones were the most effective.

The first, from Washington University in St. Louis, found that a 25% stronger dose of radiation used to treat patients with one type of lung cancer were more dangerous for the patients — and less effective in treating the disease.

The study, of patients with non-small cell lung cancer who were also receiving chemotherapy, showed an increase in “local failure,” meaning cancer cells at the radiation site either weren’t killed or began growing.

“Many doctors expected that using a higher dose of radiation would mean better outcomes for patients, so this was a surprising result,” Swain said. “This study should put an end to discussions about higher dose treatments.”

A second study looked at the efficacy of post-surgery chemotherapy and radiation for patients with seminoma, a common type of testicular cancer, versus follow-up monitoring of the patients.

Researchers looked at 1,800 patients with stage 1 seminoma in Denmark, where the typical post-surgery treatment protocol calls for regular clinic visits, CT scans, X-rays and blood work — not chemo or radiation. However, many U.S. treatment centers do use chemo and radiation as part of post-surgery treatment.

More than 80% of patients did not relapse after surgery, the study found, eliminating the need for follow-up chemotherapy or radiation. In those who did relapse, follow-up treatment led to a 99.5% survival rate.

“In this study, we see that surveillance alone was safe,” said Dr. Clifford Hudis, president-elect of the American Society of Clinical Oncology.

The final study looked at whether patients with a particular form of non-Hodgkin lymphoma should have regular CT scans to detect relapses after they finish treatment. The study showed most relapses weren’t detected by the scans, but by patients’ complaints of symptoms, routine physical exams or blood work.

“We can spare patients from the cost and excessive radiation from follow-up CT scans,” Hudis said.

The final study looked at a new class of drugs called PI3K delta inhibitors, being tested in patients with chronic lymphocytic leukemia.

The specific drug tested in the trial — Idelalisib — was shown in a first phase of study to be safe in high-risk populations, and to help reduce the size of affected lymph nodes for long periods of time. It may soon lead to alternatives to chemo for slow-growing blood cancers, Swain said.

Wednesday 120509

Workout

Run 3M or Row 5k…at less than 100% effort

One more easy day…Thursday, will be CFT (CrossFit Total) and Friday

A depressing read from The Daily Beast

Why the Campaign to Stop America’s Obesity Crisis Keeps Failing

The government has spent hundreds of millions telling Americans to exercise more and eat less. But the country is getting heavier every year. It’s time to change the way we think about fat.

by  |

Most of my favorite factoids about obesity are historical ones, and they don’t make it into the new, four-part HBO documentary on the subject, The Weight of the Nation. Absent, for instance, is the fact that the very first childhood-obesity clinic in the United States was founded in the late 1930s at Columbia University by a young German physician, Hilde Bruch. As Bruch later told it, her inspiration was simple: she arrived in New York in 1934 and was “startled” by the number of fat kids she saw—“really fat ones, not only in clinics, but on the streets and subways, and in schools.”

What makes Bruch’s story relevant to the obesity problem today is that this was New York in the worst year of the Great Depression, an era of bread lines and soup kitchens, when 6 in 10 Americans were living in poverty. The conventional wisdom these days—promoted by government, obesity researchers, physicians, and probably your personal trainer as well—is that we get fat because we have too much to eat and not enough reasons to be physically active. But then why were the PC- and Big Mac–-deprived Depression-era kids fat? How can we blame the obesity epidemic on gluttony and sloth if we easily find epidemics of obesity throughout the past century in populations that barely had food to survive and had to work hard to earn it?

These seem like obvious questions to ask, but you won’t get the answers from the anti-obesity establishment, which this month has come together to unfold a major anti-fat effort, including The Weight of the Nation, which begins airing May 14 and “a nationwide community-based outreach campaign.” The project was created by a coalition among HBO and three key public-health institutions: the nonprofit Institute of Medicine, and two federal agencies, the Centers for Disease Control and Prevention and the National Institutes of Health. Indeed, it is unprecedented to have Read more Wednesday 120509

Wednesday 090930

Tomorrow is CFT (CrossFit Total).

As Fall has arrived (and like I have said many times) it is time for us to get a bit stronger. To that end, we will Squat (e.g. Back Squat or Front Squat) 2x a week in October with a “Mini” MetCon after the Squat sessions. Tomorrow’s CFT will be the base for the design of those workouts.

So think Squatober…November will be Pressing 2x per week and December Oly lifting (or Oly lifting assistance exercises). In 2010 we will be stronger and continue to get fit!

Workout
Nice easy 3 Mile run or 5K row

Compare to:
TITANFIT: Tuesday 090728